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Gledwood's Drug Confessions: A Heroin Addict's Blog
Saturday, 6 January 2007
Ibogaine and Genes
Mood:  bright
Now Playing: I Want to Break Free...
Topic: Drugs Treatments

Have a look at this, folks. A gene is found (in rodents) that affects the likelihood of opiate relapse...

This New Scientist article puts me in mind of the African plant substance ibogaine, which has always been better known as a psychedelic. It's apparently not the pleasantest drugs trip you can go on (loads of nausea and vomiting)... and yet the plant has one fascinating power... it seems to be able to defeat drug addiction of all kinds. I.e. even people on huge methadone doses can, supposedly, undergo ibogaine treatment and the ibogaine not only blockades opiate craving for four years (with no need to readminister the ibogaine during that time) it also eliminates almost entirely withdrawals even from methadone (which are the worst). And it also works against crack! There's an American ibogaine clinic in my links to the right...

To read about the relapse gene in rats click:

By the way; poor rats:— did they put them on methadone afterwards?

Posted by gledwood at 10:39 PM GMT
Updated: Saturday, 6 January 2007 10:48 PM GMT
Wednesday, 3 January 2007
Mood:  vegas lucky
Now Playing: Ultra Clean
Topic: Drugs Treatments

NALTREXONE—for those who've got clean and want to stay clean.

(It's similar to the naloxone component of American Suboxone.)

Extract from a leaflet on naltrexone (Nalorex).

Treatment Choices

There are a number of drugs that can be prescribed to help you if you are dependent on opiates like heroin. Naltrexone is a drug that people who have detoxed can take to help them stay opiate-free.

   There is not, and never will be, a “magic cure” that can stop everyone taking opiates.

   However, the drug treatments, and help from the services that offer them, might be able to help you make any changes you want to make.

   This leaflet is one of a series designed to help you understand what you can expect from the different drug treatments that may be on offer.


Naltrexone is prescribed in the UK under the trade name Nalorex. You can take it if you want to be completely free of heroin and other opiates. It works by sticking to, and blocking, all of the opiate receptors in the brain.

   Before you take the first dose of naltrexone you must have been completely heroin- and methadone-free for seven to ten days. This is because if there are opiates in your system, the naltrexone will very quickly remove them from the receptors, and send you into instant withdrawal.


Naltrexone can make coping with difficult times and high-risk situations easier because you know that if you take heroin, it won’t have any effect.

   You take naltrexone as a tablet and, once you are stable and used to taking it, you can take it just three times a week to give full-time protection against the effects of heroin and all other opiates.

Other drugs

Naltrexone doesn’t provide protection against cocaine, tranquillizers or alcohol — so it is important to make sure these drugs don’t “replace” the heroin.


There has been some publicity given to naltrexone implants which are inserted surgically under the skin and give up to three months’ protection from opiates. However, these are experimental and are usually only available form a small number of private doctors.

Side effects

Sometimes people on naltrexone suffer from anxiety, stomach upsets and sleeplessness. But these feelings and physical symptoms are common following opiate detox  — whether you are on naltrexone or not. If you do get these symptoms, discuss them with your doctor before stopping treatment.

Stopping treatment

Many of the people who start naltrexone treatment stop within a few weeks. This is sometimes because of the side effects, but more often it is because they realize that they don’t really want to completely stop taking opiates.


You will be at very high risk of overdose if you stop taking naltrexone and start using heroin (or other opiates) again.

   It can be really hard to measure how tolerant you are. A few days after your last naltrexone tablet, you may be able to take as much heroin as you used to — because there is still some naltrexone in your system. Then, just a few hours later, the same dose could kill you — because the naltrexone has all gone.

   If you do stop taking naltrexone, and go back to using heroin, it is important that you don’t inject — with lower tolerance you’ll get a strong enough effect if you chase it.

   Using heroin when you have been drinking alcohol or taking other tranquillizers *like Valium or sleeping pills) also increases the risk of you dying from an overdose.


You can get more copies of “Treatment Choices” from:

Exchange Supplies, 1 Great Western Industrial Centre, Dorchester, DT1 1RD.

Tel: 01305 262244  Fax: 01305 262255  Email:


Written by Andrew Preston and Jon Derricott. © Exchange 2002. Third edition 2006.

Exchange—tools for harm reduction.

Posted by gledwood at 8:37 PM GMT
Updated: Wednesday, 3 January 2007 8:46 PM GMT

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